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One study published in 2021 compared 1961 adults in a weight-loss program using either a once-weekly semaglutide subcutaneous injection with lifestyle changes or placebo with lifestyle changes for 68 weeks

Potential Mental Health Effects of GLP-1 Treatment Clinical experience and emerging research suggest that GLP-1 receptor agonists may influence mental health in various ways, though the evidence base remains limited and findings are mixed

Hum Psychopharmacol

Gene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders

In another adjuvant breast cancer trial (the ECOG-1178 trial), hot flashes were reported in 19% of women who received 2 years of tamoxifen compared with 8% of women who received placebo following a mastectomy